N-(Cyanomethyl)-phthalimide → 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanethioamide

Participants

Reaction Steps

In a 20 ml 4N solution of hydrogen chloride in ethyl acetate, 3.07 g of phthalimidoacetonitrile was dissolved. To the resulting solution, 3.17 ml of O,O-diethyl dithiophosphate was added, followed by stirring at room temperature for 6 hours. The precipitate formed was collected by filtration, and washed successively with ethyl acetate and diethyl ether, whereby 2.29 g of phthalimidothioacetamide was obtained.

Provenance & Evidence