反应详情

In 100 ml of isopropanol, 1.64 g of 2-bromo-1-indanone was dissolved. Then, 2.0 g of phthalimidothioacetamide was added, followed by heating under reflux for 6 hours. The precipitate thus formed was collected by filtration and then distributed between chloroform and a saturated aqueous solution of sodium bicarbonate. The organic layer was separated, washed successively with water and a saturated aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate. The solvent was then evaporated, whereby 1.3 g of 2-phthalimidomethyl-8H-indeno[1,2-d]thiazole was obtained.

1. temperatureby heating
2. temperatureunder reflux for 6 hours
3. customThe precipitate thus formed
4. filtrationwas collected by filtration
5. customThe organic layer was separated
6. washwashed successively with water
7. dry with materiala saturated aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate
8. customThe solvent was then evaporated