Hydrogen Bromide → HCID 18941037, compound

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Reaction Steps

To 0.25 g of 2-[(1-ethoxycarbonyl-4-piperidyl)methyl]-8H-indeno[1,2-d]thiazole was added 10 ml of a 25% solution of hydrogen bromide in acetic acid, followed by heating under reflux for one hour. After cooling, water was added, and the mixture was alkalized with a 1N aqueous solution of sodium hydroxide and potassium carbonate, followed by extraction with chloroform. The extract was dried over anhydrous potassium carbonate. The solvent was then evaporated, whereby 0.23 g of 2-(4-piperidylmethyl)-8H-indeno[1,2-d]thiazole was obtained. The resulting product was dissolved in methanol, fumaric acid was added thereto, followed by crystallization from acetonitrile. The crystals were recrystallized from acetonitrile-methanol to give a fumarate.

Provenance & Evidence