Potassium Carbonate → HCID 18941131, compound

Participants

Reaction Conditions

Reaction Steps

In 0.13 ml of formic acid and 0.3 ml of a 35% aqueous formaldehyde solution, 94 mg of 2-(3-piperidylmethyl)-8H-indeno[1,2-d]thiazole was dissolved, followed by heating at 90° C. for 14 hours. The reaction mixture was diluted with water and chloroform, followed by the addition of potassium carbonate to adjust the pH of the aqueous layer to about 8. An organic layer was separated, and the resulting aqueous layer was extracted twice with chloroform. The organic layers were combined and washed with a saturated aqueous solution of sodium chloride. After drying over anhydrous sodium sulfate, the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: chloroform-methanol), whereby 99 mg of a brawn oily substance was obtained. The substance was dissolved in 1 ml of acetonitrile, and 40 mg of fumaric acid was added thereto. The resulting mixture was stirred at room temperature for 30 minutes and the crystals formed were collected by filtration, whereby 90 mg of 2-[(1-methyl-3-piperidyl)methyl]-8H-indeno[1,2-d]thiazole fumarate was obtained.

Provenance & Evidence