HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 356131Generated: October 27, 2026
Oxindole → 3-[(3,4-Dimethylpyrrol-2-yl)methylene]-2-indolinone
https://huagongshe.com/reaction/356131
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxindole | HCID 321710 | — |
| Reactant | 3,4-dimethyl-1H-pyrrole-2-carboxaldehyde | HCID 579626 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-[(3,4-Dimethylpyrrol-2-yl)methylene]-2-indolinone | HCID 49823624 | 73.6% |
Reaction Steps
A reaction mixture of 67.0 mg (0.5 mmoles) of oxindole, 73.0 mg (0.6 mmoles) of the 3,4-dimethylpyrrole-2-carboxaldehyde, and 2 drops of piperidine in 2 mL of ethanol was stirred at 90° C. for 3 h. After cooling, the precipitate was filtered, washed with cold ethanol, and dried to yield 87.7 mg (37%) of the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05834504 |
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| Source dataset | uspto-grants-1998_11 |
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| ORD ID | ord-ec737feba6184f2ca8acfc7f4a65731d |
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| Source note | uspto-grants-1998_11 |
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