Sodium hydride → HCID 18940562, compound

Participants

Reaction Steps

To a solution of 1-benzyl-4-methyl-1,3-dihydro-1,5-benzodiazepin-2(2H)-one (3.0 g, 13.1 mmol) in N-dimethylformamide (20 mL) was added sodium hydride (content 60%, 0.51 g, 12.8 mmol). The mixture was stirred for 15 minutes, to which was added 4-methoxybenzylbromide (2.3 g, 11.5 mmol), and the mixture was stirred for further 30 minutes. The reaction mixture was diluted with water, which was extracted with ethyl acetate. The extract was washed with water, dried and concentrated. The concentrate was crystallized from ethyl acetate-hexane to give 3.3 g of the titled compound. Yield 76%. m.p. 136°-137° C.

Provenance & Evidence