Ethanol hydrochloride → (3aR*,10aS*)-9-Benzyl-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one hydrochloride

HRID 356151Notes

Reaction equation

HRID 356151 reaction equation
[ClH:1].C(O)C.[CH2:5]([N:12]1[C:18](=[O:19])[C@H:17]2[CH2:20][CH2:21][CH2:22][C@H:16]2[NH:15][C:14]2[CH:23]=[CH:24][CH:25]=[CH:26][C:13]1=2)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(O)C>[ClH:1].[CH2:5]([N:12]1[C:18](=[O:19])[C@H:17]2[CH2:20][CH2:21][CH2:22][C@H:16]2[NH:15][C:14]2[CH:23]=[CH:24][CH:25]=[CH:26][C:13]1=2)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 70109795(3aR*,10aS*)-9-benzyl-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta [e][1,4]diazepin-10(1H)-one

Product 1

HCID 70111935(3aR*,10aS*)-9-Benzyl-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In ethanol was dissolved (3aR*,10aS*)-9-benzyl-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one. To the solution was added dropwise a 2.5N HCl-ethanol solution, and the mixture was concentrated under reduced pressure. The concentrate was recrystallized from ethanol-ether to give the titled compound. m.p. 145°-148° C.

Workup

  1. concentrationthe mixture was concentrated under reduced pressure
  2. customThe concentrate was recrystallized from ethanol-ether

Sources & evidence

ORD record
ord-73df44f84f6d41899bb8ef19f4c809a0
Source dataset
uspto-grants-1998_11
Patent number
US05834463

Reaction notes

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