Ethanol hydrochloride → (3aR*,10aS*)-9-(4-Nitrobenzyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one hydrochloride

Participants

Reaction Steps

In ethanol was suspended (3aR*,10aS*)-9-(4-Nitrobenzyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]-diazepin-10(1H)-one produced in Working Example 26. To the suspension was added an HCl-ethanol solution, and the mixture was stirred. Resulting crystalline precipitate was collected by filtration, which was washed with ethanol to give the titled compound, m.p. 167°-170° C.

Provenance & Evidence