HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenethylamine → Benzyl-4-(phenethylaminoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]-diazepin-10(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenethylamine | HCID 1001 | — |
| Reactant | (3aR*,10aS*)-9-benzyl-4-(bromoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]-cyclopenta[e][1,4]diazepin-10(1H)-one | HCID 70109710 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Benzyl-4-(phenethylaminoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]-diazepin-10(1H)-one | HCID 86753324 | 48% |
Reaction Steps
Using (3aR*,10aS*)-9-benzyl-4-bromoacetyl-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopent[e][1,4]-diazepin-10(1H)-one and phenethylamine, the titled compound was synthesized in substantially the same manner as in Working Example 138 in a yield of 48%, m.p. 108°-109° C. (diethyl ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05834463 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-5c6506a4346545f7a3aae45de4294e01 |
| Source note | uspto-grants-1998_11 |