反应详情

A suspension of (3aR*,10aS*)-9-(4-nitrobenzyl)-4-(phthalimidoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one (110 mg, 0.21 mmol) and platinum oxide (20 mg) in methanol (20 mL) was stirred for 12 hours at room temperature under hydrogen atmosphere. The reaction mixture was subjected to filtration, and the filtrate was concentrated under reduced pressure, which was crystallized from diethyl ether to give 72 mg (yield 81%) of the object compound, m.p.286°-289° C.

1. filtrationThe reaction mixture was subjected to filtration
2. concentrationthe filtrate was concentrated under reduced pressure, which
3. customwas crystallized from diethyl ether