HCID 18940610, compound → HCID 18940563, compound

Participants

Reaction Steps

To a solution of 1-benzyl-4-(benzyloxy-carbonylamino methyl)-5-(phthalimidoacetyl)-1,3,4,5-tetrahydro-1,5-benzodiazepin-2(2H)-one (1.51 g, 2.5 mol) in chloroform (20 mL) was added 25% hydrogen bromide-acetic acid solution (5 mL). The mixture was stirred for 25 minutes at room temperature, which was concentrated under reduced pressure. The concentrate was crystallized from ethanol-diethyl ether, followed by recrystallization from dichloromethane-ethanol-diethyl ether to afford the object compound (1.13 g, 82%), m.p.232°-234° C.

Provenance & Evidence