HCID 67779826, compound → HCID 18940613, compound

Participants

Reaction Steps

To a solution of 9-(3-phenyl-2-propen-1-yl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one (1.0 g, 3.1 mmol) in methanol (10 mL) was added 10% palladium-carbon (hydrous) (0.1 g). The mixture was stirred for 30 minutes at room temperature under hydrogen atmosphere. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. To the concentrate were added ethyl acetate and hexane. Insoluble material was filtered off, and the filtrate was concentrated, which was subjected to a silica-gel column chromatography (hexane-ethyl acetate 10:1) to afford the desired product (10.90 g, 90%) as an oily product.

Provenance & Evidence