HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → 1H-Pyrrolo[2,3-b]pyridine-1-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | methyl 2-(1H-pyrrolo[2,3-b]pyridin-1-yl)acetate | HCID 23298344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1H-Pyrrolo[2,3-b]pyridine-1-ethanol | HCID 13285357 | 87.1% |
Reaction Steps
A procedure similar to that described in Preparation 2 was repeated, except that 7.50 g of methyl 7-azaindol-1-acetate (prepared as described in Preparation 17), 1.80 g of lithium aluminum hydride and 260 ml of anhydrous tetrahydrofuran were used, to give 5.57 g of the title compound, melting at 52.7°-53.3° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05834501 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-55bfae11fed14fc2a0c9104d50318b13 |
| Source note | uspto-grants-1998_11 |