Chlorotrimethylsilane → HCID 18630201, compound

HRID 356351Notes

Reaction equation

HRID 356351 reaction equation
[CH2:1]([NH:3][C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:2].[CH3:12][Si:13](Cl)([CH3:15])[CH3:14]>>[CH2:1]([NH:3][C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Si:13]([CH3:15])([CH3:14])[CH3:12])[CH3:2]

Participants

3

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 11959N-Ethylbenzamide

Product 1

HCID 18630201HCID 18630201, compoundYield 68.3%

Procedure

N-Ethylbenzamide (74.5 g, 500 mmol) and TMSCl (135.8 g, 1.25 mol) were combined according to General Method C and purified by HPLC with 1:4 ethyl acetate/hexanes to afford 75.59 g of the title compound, as a white solid, a 68% yield. m.p. 64.0°-66.0° C.

Workup

  1. custompurified by HPLC with 1:4 ethyl acetate/hexanes

Sources & evidence

ORD record
ord-74b7af9748c941d2824e5477deb5adab
Source dataset
uspto-grants-1998_11
Patent number
US05834447

Reaction notes

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