HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethyl-3-thiosemicarbazide → N-Methyl-N-[3-[3-(ethylamino)-1,2,4-triazolo[4,3-b]-pyridazin-6-yl]phenyl]propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethyl-3-thiosemicarbazide | HCID 1551780 | — |
| Reactant | N-methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide | HCID 14280298 | — |
| Product | N-Methyl-N-[3-[3-(ethylamino)-1,2,4-triazolo[4,3-b]-pyridazin-6-yl]phenyl]propanamide | HCID 15595695 | 20.4% |
Reaction Steps
A solution of 5.0 g N-methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide and 4.3 g 4-ethyl-3-thiosemicarbazide was refluxed for 18 hours. The mixture was then treated and the product chromatographed as described in Example 70. Recrystalization of the product from dichloromethane-hexane afforded 1.2 g of yellow crystals, mp 198°-199° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04767765 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-a731356be077480dbef05d8dbdd41a7c |
| Source note | uspto-grants-1988_08 |