Hydrochloric Acid → HCID 53815595, compound

Participants

Reaction Steps

5-[3'-(t-Butyidimethylsilyloxy)propyloxy]-2-nitrobenzaldehyde (5.80 g) is dissolved in dry THF (35 ml), and thereto is added with stirring vinyl-magnesium bromide (1.7 equivalent) in THF solution in a dry ice-acetone bath. The mixture is stirred for two hours, and thereto is added 5% hydrochloric acid (30 ml). The mixture is stirred at room temperature, extracted with ethyl acetate, and purified by silica gel column chromatography to give 1-{5'-[3"-(t-butyldimethylsilyloxy)propyloxy]-2'-nitrophenyl}-2-propen-1-ol (5.02 g).

Provenance & Evidence