反应详情

1 g of the compound obtained in Example 36 and 2.1 g of selenium dioxide in 40 ml of dioxan were stirred in an autoclave at 170° C. for 7 hours. The reaction mixture was filtered and the filtrate was concentrated. The residue was partitioned between ethyl acetate and water. The organic phase was dried, the solvent was evaporated and the residue was purified over silica gel with ethyl acetate/hexane. 0.53 g of 5-isopropyl-pyridine-2-sulphonic acid 5-(2-chloro-5-methoxy-phenoxy)-6-formyl-2-morpholin-4-yl-pyrimidin-4-ylamide, m.p. 194° C., was obtained.

1. filtrationThe reaction mixture was filtered
2. concentrationthe filtrate was concentrated
3. customThe residue was partitioned between ethyl acetate and water
4. customThe organic phase was dried
5. customthe solvent was evaporated
6. customthe residue was purified over silica gel with ethyl acetate/hexane