4-Fluoroaniline → HCID 18938798, compound

HRID 356663Notes

Reaction equation

[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH2:9]1[O:13][C:10]1([CH3:12])[CH3:11]>>[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH2:9][C:10]([OH:13])([CH3:12])[CH3:11])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 97314-Fluoroaniline

HCID 11208Isobutylene oxide

Product 1

HCID 18938798HCID 18938798, compoundYield 65.5%

Conditions

Temperature: 120 °C

Procedure

A mixture of 4-fluoroaniline (1.12 g, 10 mmol) and isobutene oxide (0.70 g, 10 mmol) was heated in a sealed tube at 120° C. overnight. The resultant oil was purified by flash chromatography to give the title compound as an oil (1.20 g, 65%).

Workup

customThe resultant oil was purified by flash chromatography

Sources & evidence

ORD record: ord-f6666d43e6344656b3233377072654d5
Source dataset: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05837702

Reaction notes

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