HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-methylthiazole → (3R-trans)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-[(4-methyl-2-thiazolyl)amino]-2H-1-benzopyran-6-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-methylthiazole | HCID 74143 | — |
| Reactant | (3R-trans)-[(6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl)phenylamino]acetic acid, ethyl ester | HCID 10738551 | — |
| Reactant | (1aR,7bR)-2,2-Dimethyl-1a,7b-dihydro-2H-oxireno[2,3-c]chromene-6-carbonitrile | HCID 10987295 | — |
| Product | (3R-trans)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-[(4-methyl-2-thiazolyl)amino]-2H-1-benzopyran-6-carbonitrile | HCID 10805291 | — |
Reaction Steps
The title compound was prepared from (1aR-cis)-1a,7b-dihydro-2,2-dimethyl-2H-oxireno-[c][1]benzopyran-6-carbonitrile (the title A compound of Example 3) and 2-amino-4-methyl-thiazole by the procedure described for the title compound of Example 1. The residue was purified by a flash column to give a colorless solid (730 mg, 58%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05837702 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-e22e6eae5ca64f7fb138645d58a42b2b |
| Source note | uspto-grants-1998_11 |