Trifluoroacetic acid → HCID 67650944, compound

Participants

Reaction Steps

Using a similar procedure to that described in Example 1, step 4, trans-1-tert-butoxycarbonyl-3-fluoro-4-[(1R)-1-phenylethylamino]piperidine (0.1147 g, 0.356 mmol) was reacted with trifluoroacetic acid (0.5 mL) in dichloromethane (1.0 mL) to give 75.6 mg (96%) of the title compound as a colourless oil. δH (250 MHz, CDCl3) 1.19 (1H, m), 1.35 (3H, d, J=6.6 Hz), 1.68 (1H, m), 2.40-2.73 (3H, m), 2.85 (1H, m), 3.26 (1H, m), 3.99 (1H, q, J=6.6 Hz), 4.28 (1H, two m, J=49.8 Hz), 7.20-7.35 (5H, m).

Provenance & Evidence