HCID 18939017, compound → HCID 18939009, compound

HRID 356694Notes

Reaction equation

HRID 356694 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[C:11]([C:19]([O:21]CC3C=CC=CC=3)=[O:20])[C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:4][CH:3]=1>CCO.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[NH:9][C:10]([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[C:11]([C:19]([OH:21])=[O:20])[C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 18939017HCID 18939017, compound

Product 1

HCID 18939009HCID 18939009, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of benzyl 2-(4-fluorophenyl)-3-(4-pyridyl)-5-phenyl-pyrrole-4-carboxylate from Example 125 (1.0 mmol), 0.01 g of 10% Pd/C in 5 mL of EtOH will yield 2-(4-fluorophenyl)-3-(4-pyridyl)-5-phenyl-pyrrole-4-carboxylic acid after treatment with 40 psi H2 followed by filtration.

Sources & evidence

ORD record
ord-28bccaabcd3e45ceaa17466fda346c50
Source dataset
uspto-grants-1998_11
Patent number
US05837719

Reaction notes

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