4-tert-Butylcyclohexanol → 4-t-Butylcyclohexyl chlorooxalate

Participants

Reaction Steps

In this example the product was prepared in two synthetic steps. In the first step 4-t-butylcyclohexanol was reacted with 50% molar excess of oxalyl chloride. Upon completion of the reaction the excess oxalyl chloride was stripped from the product at reduced pressure to produce 4-t-butylcyclohexyl chlorooxalate having an assay of 96.9% and in a corrected yield of 95.3%. In the second step 4-t-butylcyclohexyl chlorooxalate was reacted with 2,5-dimethyl-2,5-dihydroperoxyhexane, in the presence of pyridine, to yield the product:

Provenance & Evidence