Trifluoroacetic acid → HCID 18702171, compound

Participants

Reaction Steps

N-tert-butyloxycarbonyl-N'-fluorenylmethyloxycarbonylethylene-diamine (20.0 g, 0.052 mol) was treated with trifluoroacetic acid and anisole in dichloromethane (10:10:1) for 1 hour at room temperatute. After evaporation to dryness the crude product was crystallized from solvent mixture of ethyl acetate-n-hexane. Yield 15.0 g (73%). NMR (300 MHz, DMSO-d6, 25° C.) d: 2.85 (m, 2H, CaH2), 3.22 (m, 2H, CbH2), 4.23-4.36 (m, 3H, Fmoc OCH2CH--), 7.37 (m, 1H, NH), 7.34-7.89 (m, 8H, Fmoc), 7.77 (br, 2H, NH2). M.p. 128°-129° C.

Provenance & Evidence