p-Toluenesulfonic acid → HCID 22107627, compound

Participants

Reaction Steps

3.0 g (7.1 mmol) of 1-(4-bromo-5-difluoromethoxy-1-methyl-3-pyrazolyl)-5-(1,1-diethoxyethyl)-1H-pyrazole-4-carbonitrile are dissolved in 50 ml of toluene, and 6.3 g (71 mmol) of cis-2,3-butene-1,4-diol and a catalytic amount of p-toluenesulfonic acid are then added. The mixture is kept at the boil for half an hour under a water separator, and the cooled solution is washed with sodium chloride solution, dried with magnesium sulfate and concentrated. The residue is purified by column chromatography.

Provenance & Evidence