反应详情

S-(+)-ibuprofen (5.0 g; 0.024 mole) was shed into methanol (35 ml), concentrated sulfuric acid (1 ml) was added and the reaction mixture was heated for 3 hours at the reflux temperature of the reaction mixture. Then it was evaporated in vacuo at the temperature of 30° C. to dryness. S-(+)-ibuprofen methyl ester (5.1 g) was obtained.

1. additionwas added
2. temperaturethe reaction mixture was heated for 3 hours at the reflux temperature of the reaction mixture
3. customThen it was evaporated in vacuo at the temperature of 30° C. to dryness