反应详情

温度

50 °C

9.6 g (50 mmol) of methyl 3-phenyl-2,3-epoxybutyrate are dissolved in 150 ml of benzyl alcohol, and 0.5 ml of concentrated sulfuric acid is added. The mixture is stirred at 50° C. for 6 hours and allowed to cool to room temperature. After neutralization with sodium bicarbonate solution, the excess benzyl alcohol is removed by distillation under high vacuum, and the residue is purified by flash chromatography on silica gel with 9:1 n-hexane/ethyl acetate. After removal of the solvent by distillation, 6.5 g of a colorless oil remain.

1. temperatureto cool to room temperature
2. customAfter neutralization with sodium bicarbonate solution, the excess benzyl alcohol is removed by distillation under high vacuum
3. customthe residue is purified by flash chromatography on silica gel with 9:1 n-hexane/ethyl acetate
4. customAfter removal of the solvent
5. distillationby distillation, 6.5 g of a colorless oil