Thionyl Chloride → 3-(2-Fluorocyclopentyloxy)-4-methoxybenzoyl chloride

HRID 356907Notes

Reaction equation

HRID 356907 reaction equation
[F:1][CH:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[O:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[C:11](O)=[O:12].S(Cl)([Cl:21])=O>C1(C)C=CC=CC=1>[F:1][CH:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[O:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[C:11]([Cl:21])=[O:12]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 211879463-(2-Fluorocyclopentyloxy)-4-methoxybenzoic acid

Product 1

HCID 211878913-(2-Fluorocyclopentyloxy)-4-methoxybenzoyl chloride

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
60 °C

Procedure

A suspension of 3-(2-fluorocyclopentyloxy)-4-methoxybenzoic acid (0.48 g) in toluene (20 mL) is treated with thionyl chloride (0.34 g) and then is heated at 60° C. for 3 hours, and cooled and evaporated to give 3-(2-fluorocyclopentyl-oxy)-4-methoxybenzoyl chloride.

Workup

  1. temperaturecooled
  2. customevaporated

Sources & evidence

ORD record
ord-8819fcd8b9b7445cbb74d8288f4d0aa8
Source dataset
uspto-grants-1998_11
Patent number
US05840724

Reaction notes

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