反应详情

A stirred solution of potassium permanganate (28 g) in acetone (200 mL) is treated with 2-methoxy-5-formylphenyl benzoate (35.2 g; that is prepared as described in Reference Example 8), and the resulting vigorously reacting mixture is cooled in an ice bath. It is then stirred at room temperature for 3 hours. The mixture is then concentrated and the residue is treated with saturated aqueous sodium metabisulfite solution (300 mL). The resulting white solid is filtered off, washed well with water (200 mL), and dried, to give 3-benzoyloxy-4-methoxy-benzoic acid (29.3 g), m.p. 180°-183° C.

1. customthat is prepared
2. temperatureis cooled in an ice bath
3. concentrationThe mixture is then concentrated
4. additionthe residue is treated with saturated aqueous sodium metabisulfite solution (300 mL)
5. filtrationThe resulting white solid is filtered off
6. washwashed well with water (200 mL)
7. customdried