Potassium Carbonate → HCID 86751427, compound

Participants

Reaction Steps

A stirred solution of 3-hydroxy-4-methoxy- benzaldehyde (5.74 g) in dry dimethylformamide (50 mL) is treated with cyclopentylmethyl bromide (7.34 g) and potassium carbonate (15 g), and the solution is heated at 600C for 24 hours. After cooling and filtration, the solution is evaporated to low bulk and dissolved in ethyl acetate (100 mL). The organic solution is washed with aqueous sodium hydroxide solution (4×50 mL; 2 N) and water (2×50 mL), dried over magnesium sulfate, and evaporated to give 3-cyclopentyl- methoxy- 4-methoxybenzaldehyde (6.5 g) in the form of a light brown oil.

Provenance & Evidence