Pyridine → HCID 18936915, compound

HRID 356985Notes

Reaction equation

HRID 356985 reaction equation
[C:1]([O:4][C:5](=[O:7])[CH3:6])(=O)[CH3:2].OC1[C:10]([C:19]([NH2:21])=[O:20])=[CH:11][C:12]2[C:17](C=1)=[CH:16][CH:15]=[CH:14][CH:13]=2.N1C=CC=CC=1>>[C:5]([O:4][C:1]1[C:10]([C:19]([NH2:21])=[O:20])=[CH:11][C:12]2[C:17]([CH:2]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2)(=[O:7])[CH3:6]

Participants

4

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 193172-Naphthalenecarboxamide, 3-hydroxy-

Product 1

HCID 18936915HCID 18936915, compound

Procedure

Acetic anhydride (19.2 ml, 200 mmol) was added to a solution of 18 (29.95 g, 160 mmol) in pyridine (32 ml, 400 mmol) and the mixture was maintained at room temperature for 30 minutes. The solid was filtered off, washed with acetone and dried (MgSO4), generating 27.06 g (74%) of 19 as pale yellow crystals, mp 201°-202° C. (lit. 203°-205° C.).

Workup

  1. filtrationThe solid was filtered off
  2. washwashed with acetone
  3. dry with materialdried (MgSO4)
  4. custom27.06 g (74%) of 19 as pale yellow crystals, mp 201°-202° C. (lit. 203°-205° C.)

Sources & evidence

ORD record
ord-e1a40066d05841c2807e5b2bbd80f3ae
Source dataset
uspto-grants-1998_11
Patent number
US05840739

Reaction notes

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