HCID 14976555, compound → HCID 67614656, compound

Participants

Reaction Steps

To a stirred solution of 5-hydroxy-3-(quinol-4-ylmethylene)-2-oxindole (2.883 g, 10 mmol) in pyridine (10 ml) was added gradually glycoloyl chloride (0.945 g, 10 mmol) at 0°-5° C. under cooling. The reaction mixture was stirred for about 4 h at 0°-5° C. and then for 15 h at room temperature. The mixture was poured onto an ice-water mixture, the precipitate filtered off, the residue washed thoroughly with water and then chromatographed on silica gel, using CHCl3 --MeOH mixtures as eluant. Thus pure title compound was obtained in about 60% yield.

Provenance & Evidence