Thiazolidinedione → HCID 18936790, compound

HRID 357006Notes

Reaction equation

HRID 357006 reaction equation
Cl[CH2:2][CH2:3][S:4][C:5]1[N:10]2[CH:11]=[CH:12][N:13]=[C:9]2[CH:8]=[CH:7][CH:6]=1.[S:14]1[CH2:18][C:17](=[O:19])[NH:16][C:15]1=[O:20]>>[N:13]1[CH:12]=[CH:11][N:10]2[C:5]([S:4][CH2:3][CH2:2][N:16]3[C:17](=[O:19])[CH2:18][S:14][C:15]3=[O:20])=[CH:6][CH:7]=[CH:8][C:9]=12

Participants

3

Reactant 2

HCID 5437ThiazolidinedioneHCID 18936671HCID 18936671, compound

Product 1

HCID 18936790HCID 18936790, compound

Procedure

Using 2.29 g (10.8 mmol) of 5-(2-chloroethylthio)-imidazo[1,2-a]pyridine, 1.27 g (10.8 mmol) of thiazolidine-2,4-dione and 1.62 ml (10.8 mmol) of 1,8-diazabicyclo-[5.4.0]-7-undecene, the same procedure as in Reference Example 2 was followed, to yield 1.49 g (38.7%, light orange crystal) of the desired product.

Sources & evidence

ORD record
ord-e838818f56f644808b5c5f3a6b242697
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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