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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 357050Generated: October 30, 2026

Hydrochloric Acid → 5-Ethylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione hydrochloride

https://huagongshe.com/reaction/357050

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant5-Ethylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dioneHCID 57183109—
SolventMethanolHCID 887—
Product5-Ethylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione hydrochlorideHCID 86753344—

Reaction Steps

To a solution of 0.48 g (1.38 mmol) of 5-ethylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione in 50 ml of methanol, 0.25 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 0.54 g (100%, yellow oily substance) of the desired product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05840732
Source datasetuspto-grants-1998_11
ORD IDord-fedb9ea52b21414c889418836b023284
Source noteuspto-grants-1998_11