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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 357082Generated: October 30, 2026

Hydrochloric Acid → 5-Butylidene-3-[4-(2-phenylimidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione hydrochloride

https://huagongshe.com/reaction/357082

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant5-Butylidene-3-[4-(2-phenylimidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dioneHCID 57049802—
SolventMethanolHCID 887—
Product5-Butylidene-3-[4-(2-phenylimidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione hydrochlorideHCID 73472969—

Reaction Steps

To a solution of 1.70 g (3.90 mmol) of 5-butylidene-3-[4-(2-phenylimidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione in 20 ml of methanol, 0.4 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 1.80 g (97.7%, yellow solid) of the desired product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05840732
Source datasetuspto-grants-1998_11
ORD IDord-b9fb6f00b21a450e83f7c039c04b54d2
Source noteuspto-grants-1998_11