Hydrogen chloride-ethyl acetate → 5-(3-Phenylpropylidene)-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]oxazolidine-2,4-dione hydrochloride

HRID 357094Notes

Reaction equation

HRID 357094 reaction equation
[C:1]1([CH2:7][CH2:8][CH:9]=[C:10]2[O:14][C:13](=[O:15])[N:12]([CH2:16][CH2:17][CH2:18][CH2:19][S:20][C:21]3[N:26]4[CH:27]=[CH:28][N:29]=[C:25]4[CH:24]=[CH:23][CH:22]=3)[C:11]2=[O:30])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:31].C(OCC)(=O)C>CO>[ClH:31].[C:1]1([CH2:7][CH2:8][CH:9]=[C:10]2[O:14][C:13](=[O:15])[N:12]([CH2:16][CH2:17][CH2:18][CH2:19][S:20][C:21]3[N:26]4[CH:27]=[CH:28][N:29]=[C:25]4[CH:24]=[CH:23][CH:22]=3)[C:11]2=[O:30])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 572607645-(3-Phenylpropylidene)-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]oxazolidine-2,4-dione

Product 1

HCID 702055945-(3-Phenylpropylidene)-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]oxazolidine-2,4-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a methanol solution of 26 mg (0.062 mmol) of 5-(3-phenylpropylidene)-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]oxazolidine-2,4-dione, 0.02 ml of 4N hydrochloric acid-ethyl acetate was added, followed by stirring, after which the solvent was distilled off, to yield 29 mg (quant, yellow oily substance) of the desired product.

Workup

  1. distillationafter which the solvent was distilled off

Sources & evidence

ORD record
ord-ee2d08e61d8b4b0881b1d0a4a1a54a51
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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