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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 357148Generated: October 29, 2026

Hydrochloric Acid → 5-Butylidene-3-[3-(imidazo[1,2-a]pyridin-8-yloxy)propyl]thiazolidine-2,4-dione hydrochloride

https://huagongshe.com/reaction/357148

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant5-Butylidene-3-[3-(imidazo[1,2-a]pyridin-8-yloxy)propyl]thiazolidine-2,4-dioneHCID 57096226—
SolventMethanolHCID 887—
Product5-Butylidene-3-[3-(imidazo[1,2-a]pyridin-8-yloxy)propyl]thiazolidine-2,4-dione hydrochlorideHCID 73472952—

Reaction Steps

To a solution of 1.07 g (3.10 mmol) of 5-butylidene-3-[3-(imidazo[1,2-a]pyridin-8-yloxy)propyl]thiazolidine-2,4-dione in 50 ml of methanol, 0.30 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 1.16 g (97.9%, light orange foamy substance) of the desired product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05840732
Source datasetuspto-grants-1998_11
ORD IDord-9733578048d345b986a1bff5bfcc557d
Source noteuspto-grants-1998_11