Hydrogen chloride-ethyl acetate → HCID 73472929, compound

HRID 357192Notes

Reaction equation

HRID 357192 reaction equation
[CH:1](=[C:11]1[S:15][C:14](=[O:16])[N:13]([CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[C:23]3[N:24]([CH:28]=[CH:29][N:30]=3)[CH:25]=[CH:26][CH:27]=2)[C:12]1=[O:31])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[ClH:32].C(OCC)(=O)C>CO>[ClH:32].[CH:1](=[C:11]1[S:15][C:14](=[O:16])[N:13]([CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[C:23]3[N:24]([CH:28]=[CH:29][N:30]=3)[CH:25]=[CH:26][CH:27]=2)[C:12]1=[O:31])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57223924HCID 57223924, compound

Product 1

HCID 73472929HCID 73472929, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a methanol solution of 2.12 g (4.8 mmol) of 5-decylidene-3-[4-(imidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione, 1.25 ml of 4N hydrochloric acid-ethyl acetate was added, followed by stirring. After the solvent was distilled off, the residue was washed with ether to yield 1.88 g (81.6%, white solid) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with ether

Sources & evidence

ORD record
ord-aafea47a6d914447813b2372abd6d612
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

Loading…