反应详情

温度

0 °C

To 8.5 g. (0.224 m) of lithium aluminum hydride in 250 ml. of diethyl ether under nitrogen was added 53.5 g. (0.206 m) of methyl 3-(R)-methyl-5-(t-butyldimethylsilyloxy)pentanoate in 125 ml. of ether. The reaction was stirred for one hour at 0° C. and was then treated dropwise with 8.4 g. of water, 8.4 ml. of a 15% sodium hydroxide solution and 25.2 ml. of water. The solids were filtered and the organic phase separated and washed with water, 2.5% hydrochloric acid and a brine solution. The organic phase was dried over magnesium sulfate and concentrated in vacuo to give 46 g. of product.

1. additionwas then treated dropwise with 8.4 g
2. filtrationThe solids were filtered
3. customthe organic phase separated
4. washwashed with water, 2.5% hydrochloric acid
5. dry with materialThe organic phase was dried over magnesium sulfate
6. concentrationconcentrated in vacuo
7. customto give 46 g