Hydrogen chloride-ethyl acetate → HCID 70205032, compound

HRID 357202Notes

Reaction equation

HRID 357202 reaction equation
[O:1]=[S:2]1(=[O:39])[CH2:7][CH2:6][CH2:5][N:4]2[C:8](=[O:38])[N:9]([CH2:19][CH2:20][CH2:21][NH:22][C:23](=[O:37])[CH2:24][CH2:25][CH2:26][S:27][C:28]3[N:33]4[CH:34]=[CH:35][N:36]=[C:32]4[CH:31]=[CH:30][CH:29]=3)[C:10](=[O:18])[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:3]12.[ClH:40].C(OCC)(=O)C>CO>[ClH:40].[O:39]=[S:2]1(=[O:1])[CH2:7][CH2:6][CH2:5][N:4]2[C:8](=[O:38])[N:9]([CH2:19][CH2:20][CH2:21][NH:22][C:23](=[O:37])[CH2:24][CH2:25][CH2:26][S:27][C:28]3[N:33]4[CH:34]=[CH:35][N:36]=[C:32]4[CH:31]=[CH:30][CH:29]=3)[C:10](=[O:18])[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:3]12

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57242608HCID 57242608, compound

Product 1

HCID 70205032HCID 70205032, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a methanol solution of 683 mg (1.2 mmol) of 4-(imidazo[1,2-a]pyridin-5-ylthio)butanoic [3-(1,1,6,8-tetraoxo-9-phenyl-2,3,4,8-tetrahydropyrimido[6,1-b][1,3]thiazine-7-yl)propyl]amide, 0.5 ml of 4N hydrochloric acid-ethyl acetate was added, followed by stirring. After the solvent was distilled off, the residue was washed with ether to yield 658 mg (90.7%, white crystal) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with ether

Sources & evidence

ORD record
ord-2731e8e7cfec4b1692e116202dabfcc6
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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