Hydrogen chloride-ethyl acetate → HCID 73472968, compound

HRID 357212Notes

Reaction equation

HRID 357212 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH:10]=[C:11]1[S:15][C:14](=[O:16])[N:13]([CH2:17][CH2:18][CH2:19][CH2:20][S:21][C:22]2[N:27]3[CH:28]=[CH:29][N:30]=[C:26]3[CH:25]=[CH:24][CH:23]=2)[C:12]1=[O:31].Cl.C(OCC)(=O)C>CO>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH:10]=[C:11]1[S:15][C:14](=[O:16])[N:13]([CH2:17][CH2:18][CH2:19][CH2:20][S:21][C:22]2[N:27]3[CH:28]=[CH:29][N:30]=[C:26]3[CH:25]=[CH:24][CH:23]=2)[C:12]1=[O:31]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57112842HCID 57112842, compound

Product 1

HCID 73472968HCID 73472968, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a methanol solution of 1.37 g (2.9 mmol) of 5-[3-(2-chlorophenyl)propylidene]-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione, 1.0 ml of 4N hydrochloric acid-ethyl acetate was added, followed by stirring, after which the solvent was distilled off, to yield 1.23 g (83.1%, brown oily substance) of the desired product.

Workup

  1. distillationafter which the solvent was distilled off

Sources & evidence

ORD record
ord-28d5cdcb8b6a4f53ba6a9c008e85703e
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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