Water → HCID 18936595, compound

Participants

Reaction Steps

Treat a solution of the product of step 1 (1.5 g, 4.02 mmol) in dry CH3OH (15 mL) under N2 with Cs2CO3 (1.57 g, 4.8 mmol, 1.2 eq). Stir for 30 min, then pour the suspension into Et2O (200 mL)/water (100 mL). Extract the aqueous layer with Et2O (100 mL), wash the combined ether layers with 40 mL of saturated NaCl, dry (MgSO4), and concentrate to give 1.11 g (4.02 mmol,>99%) of methyl β-(3,4-dichlorophenyl)-oxiranepropanoate as a colorless oil.

Provenance & Evidence