HRID357267

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

$结构：CCOC(=O)/C(CCO)=C(\c1ccc(Cl)cc1)c1ccc(S(C)(=O)=O)cc1$

HCID11112334

未命名化合物

PRODUCTS

生成物

$结构：CS(=O)(=O)c1ccc(/C(=C(\CCO)C(=O)[O-])c2ccc(Cl)cc2)cc1.[Na+]$

HCID23676214

未命名化合物

收率 101.6%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

To a solution of 5 g (0.0122 mole) of ethyl (Z)-3-(4-chlorophenyl)-3-(4-methanesulfonylphenyl)-2-(2-hydroxyethyl)prop-2-enoate, prepared in example 4, in 10 ml of ethanol are added 11 ml (0.011 mole) of 1M sodium hydroxide. The mixture is heated for 2 hours under reflux, then evaporated to dryness in vacuo. The crystals obtained are washed with ethyl acetate and with ethyl ether and then dried to provide 4.5 g of sodium (Z)-3-(4-chlorophenyl)-3-(4-methanesulfonylphenyl)-2-(2-hydroxyethyl)prop-2-enoate as crystals with a melting point of 257°-259° C.

WORKUP

后处理

temperatureThe mixture is heated for 2 hours
temperatureunder reflux
customevaporated to dryness in vacuo
customThe crystals obtained
washare washed with ethyl acetate and with ethyl ether
customdried