反应详情

A mixture of 3-ethoxy-4-(2-hydroxy-6-cyanophenyl)amino-3-cyclobutene-1,2-dione (0.250 g, 0.00097 mol) and tert-amylamine (1.13 ml, 0.0097 mol) was stirred in enough CH2Cl2 to form a solution at room temperature for two days. During this time a precipitate forms. The reaction solvent is evaporated on a rotary evaporator, the residue is taken up in ethyl acetate and extracted well with 0.25N HCl. The organic layer is washed once with distilled water, dried (Na2SO4), and evaporated to a solid. The solid is collected and gives 3-(tert-amylamino)-4-(2-hydroxy-6-cyanophenyl)amino-3-cyclobutene-1,2-dione, 0.135 g (0.00045 mol, 46%).

1. customto form a solution at room temperature for two days
2. customThe reaction solvent is evaporated on a rotary evaporator
3. extractionextracted well with 0.25N HCl
4. washThe organic layer is washed once with distilled water
5. dry with materialdried (Na2SO4)
6. customevaporated to a solid
7. customThe solid is collected