反应详情

To 10.0 g (69.0 mmoles) of 40 percent glyoxal and 200 ml of distilled water is rapidly added 8.0 g (69.0 mmoles) of N,N'-diethylethylenediamine. The solution is heated rapidly to reflux and heating maintained for 5 minutes. The dark brown solution is allowed to cool to room temperature and is then evaporated at 60° C. under water pump vacuum to a viscous brown oil. The oil is distilled in a short path distillation apparatus to yield 10 g (93 percent yield) of 1,4-diethylpiperazin-2-one in the form of a yellow oil. Purity is greater than 99 percent by capillary gas chromatograph.

1. temperatureThe solution is heated rapidly
2. temperatureto reflux
3. temperatureheating
4. temperaturemaintained for 5 minutes
5. customis then evaporated at 60° C. under water
6. distillationThe oil is distilled in a short path distillation apparatus