反应详情

Derivative 3 (R=4-OCH3, n=7) is prepared by a procedure similar to that described in Example 1 by reacting 1-(4-methoxyphenyl)-N-methyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide (1: R=4-OCH3) with 1-decene (2: n=7). The resulting diastereomeric mixture of cis- and trans-derivative 3 (R=4-OCH3, n=7) is flash-chromatographed on neutral silica gel using chloroform-methanol (99:1 by volume) as eluent. Isomer A has a melting point of 89°-91° C. (ethyl acetate).

1. customDerivative 3 (R=4-OCH3, n=7) is prepared by a procedure similar to
2. additionThe resulting diastereomeric mixture of cis- and trans-derivative 3 (R=4-OCH3, n=7)
3. customis flash-chromatographed on neutral silica gel