反应详情

Derivative 3 (R1 =4-Cl, R2 =CH2C6H4Cl-4 is prepared by a procedure similar to that described in Example 1 by reacting 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-N-methylethanimine N-oxide (1: R1 =4-Cl) with allyl 4-chlorobenzyl ether (2: R2 =CH2C6H4Cl-4). The resulting cis-/trans-diastereomeric mixture of the title compound (3: R1 =4-Cl, R2 =CH2C6H4Cl-4) is flash-chromatographed on neutral silica gel using chloroform-methanol (98:2 by volume) as eluent.