反应详情

Compound No. 46. A suspension of 4-phenylamino-2-amino-6-methylpyrimidine, Compound No. 45, (0.25 g) in ethanol (4 mL) was treated with methyl methanesulfonate (0.090 g) and heated at reflux for 5 days. Additional methyl methanesulfonate (0.090 g) was added and the mixture refluxed another 2 days. Concentration and recrystallization from a mixture of methanol, ethyl acetate, and tert-butyl ethyl ether gave 0.10 g of 4-phenylamino-2-amino-1,6-dimethylpyrimidinium methanesulfonate.

1. temperatureheated
2. temperatureat reflux for 5 days
3. temperaturethe mixture refluxed another 2 days
4. concentrationConcentration and recrystallization
5. additionfrom a mixture of methanol, ethyl acetate, and tert-butyl ethyl ether