反应详情

308.5 g (9.64 mol) of methanol were vaporized dropwise at 155° C. in an electrically heated column with a diameter of 4 cm and equipped with a sintered disk at the lower end and fitted onto a 250 ml two-neck flask over the course of 6 hours and passed through a melt, at 200° C., of 10 g (0.0455 mol) of 3,5-diphenylpyrazole and 0.046 g (0.000455 mol) of concentrated H2SO4. The gaseous discharge from the reaction was condensed and concentrated under reduced pressure. 10.2 g (92.5%) of 1-methyl-3,5-diphenylpyrazole were obtained, boiling point 190° C./3 mbar, with a content of 96.6% (GC).

1. customwere vaporized dropwise at 155° C. in an electrically heated column with a diameter of 4 cm
2. customequipped with a sintered disk at the lower end
3. customfitted onto a 250 ml two-neck flask over the course of 6 hours
4. customcondensed
5. concentrationconcentrated under reduced pressure