反应详情

450 mg of the 2-hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine prepared above was dissolved in 20 ml of dichloromethane to obtain a solution. 760 mg of thionyl chloride was dropwise added to this solution at 0° C. The obtained mixture was stirred at a room temperature for 2 hours. After the completion of the reaction, the reaction mixture was distilled to remove the dichloromethane and the thionyl chloride. A saturated aqueous solution of sodium hydrogencarbonate was added to the obtained residue. The obtained mixture was extracted with chloroform. The obtained chloroform layer was concentrated to obtain 470 mg of 2-chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine as a brown crystal.

1. customto obtain a solution
2. customAfter the completion of the reaction
3. distillationthe reaction mixture was distilled
4. customto remove the dichloromethane
5. additionA saturated aqueous solution of sodium hydrogencarbonate was added to the obtained residue
6. extractionThe obtained mixture was extracted with chloroform
7. concentrationThe obtained chloroform layer was concentrated