HCID 18937879, compound → Methanesulfonate

HRID 357564Notes

Reaction equation

HRID 357564 reaction equation
[CH3:1][S:2]([O:5][CH2:6][C:7]1[C:12]([CH3:13])=[C:11]([O:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][CH3:20])[CH:10]=[CH:9][N:8]=1)(=[O:4])=[O:3].[SH:21][C:22]1[NH:23][C:24]2[CH:30]=[CH:29][CH:28]=[CH:27][C:25]=2[N:26]=1>C(O)C>[CH2:19]([O:18][CH2:17][CH2:16][CH2:15][O:14][C:11]1[CH:10]=[CH:9][N:8]=[C:7]([CH2:6][S:21][C:22]2[NH:26][C:25]3[CH:27]=[CH:28][CH:29]=[CH:30][C:24]=3[N:23]=2)[C:12]=1[CH3:13])[CH3:20].[CH3:1][S:2]([O-:5])(=[O:4])=[O:3]

Participants

5

Reactant 2

HCID 18937879HCID 18937879, compoundHCID 178527775HCID 178527775, compound

Product 2

HCID 85257MethanesulfonateHCID 15166272HCID 15166272, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture comprising 4.2 g of {4-(3-ethoxypropoxy)-3-methylpyridine-2-yl}methyl methanesulfonate, 1.87 g of 2-mercaptobenzimidazole and 30 ml of ethanol was stirred at a room temperature for one hour and distilled to remove the ethanol. The obtained residue was purified by silica gel column chromatography to obtain 0.88 g of the title compound and 5.1 g of methanesulfonate of the title compound.

Workup

  1. distillationdistilled
  2. customto remove the ethanol
  3. customThe obtained residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-1a3a952952bb4578a99d14587a54395c
Source dataset
uspto-grants-1998_11
Patent number
US05840910

Reaction notes

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